Add time:08/21/2019         Source:sciencedirect.com

The first total synthesis of antifungal cyclic depsipeptide aureobasidin A is described. The synthesis was achieved mainly using bromotris(pyrrolidino)phosphonium hexafluorophosphate (PyBroP) as a coupling reagent. Peptide cyclization was carried out between L-allo-isoleucine (L-alle1) and L- Pro9 residues in the linear nonapeptide at the final step of the synthesis. Synthesized aureobasidin A was completely identical with the natural antibiotic with respect to antifungal activity and physicochemical properties. Unusual reactions due to N-methylamino acid, an oxazoline-mediated reaction and an N, O-acyl migration, are also described.

We also recommend Trading Suppliers and Manufacturers of Aureobasidin E (cas 127785-66-4). Pls Click Website Link as below: cas 127785-66-4 suppliers