Original research articleImidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes-Science-Chemical Encyclopedia-lookchem

Original research articleImidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes
Add time:08/19/2019 Source:sciencedirect.com

Background5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2 and CYP3A4.

We also recommend Trading Suppliers and Manufacturers of C 1311 (cas 138154-39-9). Pls Click Website Link as below: cas 138154-39-9 suppliers

Prev:Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions☆
Next: Polymer paperSolution behaviour of sodium maleate/1-alkene copolymers)

Click to view details

Encyclopedia