Add time:08/19/2019         Source:sciencedirect.com

The enantioselective synthesis of 2-[5-(9H-purin-9-yl)-2-cyclopenten-1-yl]ethanol analogues is described. (1R,5R)-[1-(tert-butyldimethylsilyloxy)ethyl]-2-cyclopenten-5-ol 4a and (1S,5S)-[1-(tert-butyldimethylsilyloxy)ethyl]-2-cyclopenten-5-ol 4b were coupled with 6-chloropurine and 2-amino-6-chloropurine using Mitsunobu reaction conditions. Compounds 6a & b, 7a & b, 8a & b, 9a & b, and 10a & b were tested for antiviral activity.

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