Add time:08/19/2019         Source:sciencedirect.com

A new and general one-pot synthetic method for C2-symmetric N,N′-aryl-disubstituted bis(oxazolidin-2-ones) has been developed. Highly regioselective intramolecular cyclization reactions of 2,3-di(methanesulfonyloxy)-1,4-dihydroxybutane with arylisocyanates in the presence of sodium hydride afforded the corresponding C2-symmetric N,N′-aryl-disubstituted bis(oxazolidin-2-ones) in 82–92% yields. Hydrolytic ring opening of the bis(oxazolidin-2-ones) provided a convenient synthetic route for optically pure C2-symmetric N,N′-aryl-disubstituted 2,3-diamino-1,4-butanediols (58–86% yields).

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