Add time:08/18/2019         Source:sciencedirect.com

A simple, sensitive and rapid spectrofluorimetric method to determine Velnacrine (cas 104675-29-8), a cholinesterase inhibitor, has been developed and validated. The influence of pH, temperature, ionic strength, presence of excipients, metal ions and surfactants on the fluorescence intensity has been studied. The proposed method allows the determination of 5–100 ng ml−1 of velnacrine in aqueous solution containing sodium acetate buffer (pH 5.6; 0.04 M) with λexcitation 242 nm and λemission 359 nm. The detection and quantitation limits were 1.7 and 4.5 ng ml−1 respectively. The method was successfully applied to the determination of velnacrine in human serum and urine.

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