Add time:07/14/2019         Source:sciencedirect.com

SummaryDietary administration (0.1% in a chow diet for 8 days) of 5α-cholest-8(14)-en-3β-ol-15-one, a potent inhibitor of sterol biosynthesis with marked hypocholesterolemic action, to rats caused a 77% reduction in the levels of acyl coenzyme A:cholesterol acyl transferase activity of jejunal microsomes relative to those observed in pair-fed control animals. No differences were observed in mean levels of cholesterol concentration in jejunal microsomes of experimental and pairfed control animals.

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