Add time:08/19/2019         Source:sciencedirect.com

Herein, we developed a new CL method for the detection of glucose, exhibiting high sensitivity, low limit of detection, good stability and reliability for analysis of real biological samples. The MOF-235/β-cyclodextrin (β-CD) hybrids were facilely prepared by a simple method, and characterized by XRD, TGA, FT-IR and SEM. The as-prepared hybrids exhibited highly catalytic activity for the hydrogen peroxide-luminol system, and gave more than 30-fold enhancement in CL response as compared with that of hydrogen peroxide-luminol system, thus could be used for sensitive detection of H2O2 and glucose. The excellent catalytic performance of the MOF-235/β-CD hybrids is ascribed to the large surface area of MOF-235 as well as the synergistic effect between β-CD and MOF-235. The proposed sensing strategy coupled with CL detection method showed low detection limits of 5 nM and 10 nM for H2O2 and glucose, respectively. Successful application of the MOF-235/β-CD hybrid in CL assay of glucose in real human serum samples is demonstrated as an efficient catalyst for sensitive chemiluminescence-based analyses. The success of this work favors to facilitate the future development in CL catalysts via MOF functionalization.

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