Add time:08/23/2019         Source:sciencedirect.com

The reaction of perfluorobiacetyl with thiourea produced 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione, mainly in trans-form, in a yield of ∼60%. 4,5-Dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione(one) were introduced for the first time in the condensation with thiourea in dimethylacetamide at elevated temperature and trifluoromethylated thioxo(oxo)imidazothiazolones were unexpectedly obtained (yield ∼41 − 30%). A similar reaction of 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione(one) with NH4SCN and 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione with N-alkyl(aryl)ureas and N,N'-dialkyl(diaryl)ureas afforded the same thioxo(oxo)imidazothiazolones (yield ∼50 − 16%). In contrast to it, the condensation of 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione with urea under similar conditions gave mainly trifluoromethylated thioglycoluril in ∼31% yield.

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