Add time:08/18/2019         Source:sciencedirect.com

3-[(2H-1,2,4-Benzothiadiazine-1,1-dioxide-3-yl)thio]-2-methylpropanoic acids were synthesized from the corresponding 3-mercaptoderivatives by alkylation with (+) (R)- and (−) (S)-3-bromo-2-methylpropanoic acid methyl ester. The nucleophilic substitution takes place with complete maintenance of the enantiomeric purity.

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