Add time:08/23/2019         Source:sciencedirect.com

Mononuclear Cu(II), Ni(II) and V(IV) complexes of a bidentate Schiff base ligand derived from 2-hydroxy-1-naphthaldehyde and 2-methoxyethylamine were synthesized and determined by spectroscopic methods. The crystal structures of HL ligand and Cu(II) complex was determined using single crystal X-ray diffraction method. HL Schiff base behaves as a bidentate ligand and coordinates to the metal ions via the nitrogen and oxygen. The obtained data revealed that the Cu(II) center in the complex (1) is coordinated by oxygens and nitrogens of two ligands in a regular square-planar fashion. The electrochemical behavior of the complexes was studied using cyclic voltammetry. The inhibitory activity of ligand and all the obtained complexes were tested in vitro against MKN-45 cancer cell line. It was found that among synthesized complexes, Ni(II) Schiff base complex namely (2), showed strong inhibitory activity against cancer cells, with IC50 = 6.654 ± 0.449 μg/mL.

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