Add time:08/19/2019         Source:sciencedirect.com

The review deals with the pharmaceutically important group of pyrimido[5,4-d]pyrimidines (PPs) and covers the relevant literature published from about 1986 through 2014. A synthetic section describes the formation of PPs from pyrimidines both by cyclization to give a second pyrimidine ring and by transformation of another fused heterocyclic ring. In the structure-related section, properties such as the spectroscopic and electrochemical behavior are stressed. The reactivity of PPs is dominated by the nucleophilic substitution of chloro compounds and the formation of derivatives and analogs of Dipyridamole. This useful drug is also the main focus of the application section.

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