Add time:08/19/2019         Source:sciencedirect.com

N-(8-Isopropyl-nortropan-3-α-yl)-2-methoxy-4-amino-5-chlorobenzamide has been synthesized and its crystal and molecular structures determined by X-ray diffraction, IR, 1H-NMR and 13C-NMR methods. The pyrrolidine and piperidine rings adopt a flattened N-8 envelope and distorted chair conformation puckered at N-8 and flattened at C-3 respectively, with the N-isopropyl substituent and the amido group in axial position with respect to the piperidine ring. A great predominance in solution of the conformer observed in the solid state is proposed.

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