Add time:08/20/2019         Source:sciencedirect.com

A series of 11 new 9H-bis-[1,2,4]triazolo[4,3-a:3′,4′-d] [1,5]benzodiazepine derivatives 8e–o was synthesized. Ten of these compounds (8e–m,o), along with four analogues (8a–d) (previously synthesized by us) were tested in vitro in order to evaluate their cytotoxic and anti-HIV-1 properties. In this connection other six original compounds, i.e., five 9-substituted compounds prepared starting from the 6,12-diphenylderivative 8c (compounds 10, 11, 12, 13a,b) and the bis-triazolone derivative 14, were synthesized and tested for the same purpose. While none of the 20 compounds tested exhibited any appreciable anti-HIV-1 activity, some of them exhibited interesting cytotoxic properties, the best results being shown by compounds 8c,d,k and 11 (CC50 range = 3–12 μM). Therefore, these four compounds were further evaluated for their antiproliferative activity against a panel of human tumor cell lines; actually, compounds 8d, 8k and 11 showed antiproliferative properties against either or both leukemia- and lymphoma-derived cell lines in the low micromolar range.

We also recommend Trading Suppliers and Manufacturers of 1,5-BIS-(4-CHLOROPHENYL)-BIGUANIDE HCL (cas 13590-88-0). Pls Click Website Link as below: cas 13590-88-0 suppliers