Add time:08/19/2019 Source:sciencedirect.com
Homochiral (2S, 3S)-3-benzyloxy-2-formyl-azetidines 2, (2S, 3S)-3-benzyloxy-2-carbomethoxy-azetidines 3 and the highly strained (2S)-N-p-methoxyphenyl-2-silyloxymethyl-3-azetidinone 4 were successfully synthesized starting from diethyl-L-tartrate. The suitably functionalized azetidine ring is formed in a single synthetic operation with minimum protecting group chemistry.
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