Add time:07/13/2019         Source:sciencedirect.com

A simple protocol is described for the synthesis of 2-(trifluoromethyl)benzo[b][1,8]naphthyridin-4(1H)-one derivatives. The reaction between diverse 2-chloro-3-acetyl-quinolines with trifluoroacetimidoyl chlorides using sodium hydride in THF at room temperature gives directly the title compounds without isolation of intermediates. Starting 2-chloro-3-acetyl-quinolines were easily prepared in two steps from readily available 2-chloro-3-formyl-quinolines.

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