Original articleSynthesis of 3-aryl-4-({2-[4-(6-substituted-coumarin-3-yl)-1,3-thiazol-2-yl]hydrazinylidene}methyl/ethyl)-sydnones using silica sulfuric acid and their antidiabetic, DNA cleavage activity-Science-Chemical Encyclopedia-lookchem

Original articleSynthesis of 3-aryl-4-({2-[4-(6-substituted-coumarin-3-yl)-1,3-thiazol-2-yl]hydrazinylidene}methyl/ethyl)-sydnones using silica sulfuric acid and their antidiabetic, DNA cleavage activity
Add time:08/19/2019 Source:sciencedirect.com

A novel one-pot synthesis of sydnones appended to coumarins (4a–r) via thiazole in presence of silica sulfuric acid as a heterogeneous catalyst is discussed. The use of low cost and reusable silica sulfuric acid as catalyst makes this process feasible and convenient. Further, the title compounds were screened for their α-amylase inhibition (antidiabetic) as well as DNA cleavage activities.

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