A short and efficient synthesis of echiguanines A and B: Potent inhibitors of phosphatidylinositol-4-kinase-Science-Chemical Encyclopedia-lookchem

A short and efficient synthesis of echiguanines A and B: Potent inhibitors of phosphatidylinositol-4-kinase
Add time:07/14/2019 Source:sciencedirect.com

An efficient synthesis which utilizes a palladium catalyzed carbonylation reaction between 2-pivaloyl-7-iodo-7-deazaguanine and 3-aminopropionitrile as a key step was developed for the preparation of a new class of pyrrolopyrimidine based PI4-Kinase inhibitors: Echiguanines A and B.

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