N–H Insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles☆-Science-Chemical Encyclopedia-lookchem

N–H Insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles☆
Add time:08/20/2019 Source:sciencedirect.com

Dirhodium(II) carboxylate catalysed reaction of diazocarbonyl compounds 2 in the presence of primary amides 1 results in the formation of α-acylaminoketones 3 (12 examples) by N–H insertion reaction of the intermediate rhodium carbene. The 1,4-dicarbonyl compounds 3 are readily converted into structurally diverse oxazoles 4 (11 examples) by cyclodehydration, thiazoles 5 (10 examples) by treatment with Lawesson's reagent, or imidazoles 6 (2 examples) by reaction with ammonia or methylamine.

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