Add time:08/29/2019         Source:sciencedirect.com

The retrovirus encoded proteinase (PR) is required for the proper maturation of viral particles into infectious virus. The PR had been considered highly substrate specific, cleaving exclusively the viral gag and gag-pol protein precursor. It has recently been reported, however, that cytoskeleton and other cellular filament proteins can be cleaved by the HIV-1 PR. Here we have evidence that a cell-associated protein, the fibronectin (A-chain) is also cleaved in vitro specifically by this PR. The possibility of a cytotoxic role of the PR is conceivable.

We also recommend Trading Suppliers and Manufacturers of FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 90-109 (cas 107978-81-4). Pls Click Website Link as below: cas 107978-81-4 suppliers