Add time:08/21/2019         Source:sciencedirect.com

The reaction of 3-methyl-2-cyclohexen-1-one with 2-(S)-methoxy-1,4-dibromobutane (2) produced spiro[4.5]decanone 3, a key intermediate for the synthesis of spirovetivanes, with regiodifferentiation and stereoselection. Subsequent addition of diisopropoxydimethyltitanium to the carbonyl group furnished compound 6 with diasterofacial selectivity. The same selectivity was observed in the subsequent catalytic hydrogenation.

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