Add time:08/23/2019         Source:sciencedirect.com

Tandem catalytic reaction in one-pot possesses remarkable advantages and is a powerful methodology for the synthesis of high value chemicals. Asymmetric transfer hydrogenation catalyzed by Ru-TsDPEN type catalysts, developed Noyori and Ikariya, is a useful strategy for constructing chiral alcohols and amines. Herein, a novel bifunctional Noyori-Ikariya type catalyst was developed, which displays good catalytic efficiency for Michael addition/ATH/cyclization tandem reaction. A series of chiral 3,4-dihydro-2H-pyran-5-carbonitriles were synthesized in good yield (up to 79%) and with excellent enantioselectivity (up to 97%) via this one-pot reaction under mild conditions.

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