Add time:08/20/2019         Source:sciencedirect.com

Starting from 1,2,4-tri-O-acetyl-3,6-anhydro-α-d-galactopyranose, 4-O-acetyl-3,6-anhydro-1,2-O-(1-cyanoethylidene)-α-d-galactopyranose (7) was synthesized by treatment with cyanotrimethylsilane. Additionally, 3,4-di-O-acetyl-1,2-O-(1-cyanoethylidene)-6-O-tosyl-α-d-galactopyranose was prepared from the corresponding bromide and both cyanoethylidene derivatives were used as donors in glycosylation reactions. The coupling with benzyl 2,4,6-tri-O-acetyl-3-O-trityl-β-d-galactopyranoside provided exclusively the β-linked disaccharides in approximately 30% yield. The more reactive methyl 2,3-O-isopropylidene-4-O-trityl-α-l-rhamnopyranoside gave with donors 3 and 7 the corresponding disaccharides in nearly 60% yield. Furthermore, the synthesis of 3,6-anhydro-4-O-trityl-1,2-O-[1-(endo-cyano)ethylidene]-α-d-galactopyranose, which can be used as a monomer for polycondensation reaction is described.

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