Add time:08/27/2019         Source:sciencedirect.com

A series of cysteine diazomethyl- and chloromethyl ketone derivatives has been synthesized and evaluated against human B-lineage (Nalm-6) and T-lineage (Molt-3) acute lymphoblastic leukemia cell lines. The chloromethyl ketone compounds showed potent cytotoxicity against these cell lines, with IC50 values in the low micromolar range. The best compounds were N-acetyl-S-dodecyl-Cys chloromethyl ketone (IC50=2.0 μM against Nalm-6, 2.3 μM against Molt-3) and N-acetyl-S-trans,trans-farnesyl-Cys chloromethyl ketone (IC50=3.0 μM against Nalm-6 and 1.4 μM against Molt-3).

We also recommend Trading Suppliers and Manufacturers of 1-(diazomethyl)-4-nitrobenzene (cas 19479-80-2). Pls Click Website Link as below: cas 19479-80-2 suppliers