Add time:08/20/2019         Source:sciencedirect.com

Publisher SummaryThis chapter focuses on the synthesis and applications of Pyrazol-3-ones. The chapter also highlights the reactions of the ring atoms of pyrazol-3-ones. It explores the reactivity of the ring substituents of pyrazol-3-ones. This chapter illustrates that the majority of pyrazol-3-ones have been synthesized from open chain precursors, and relatively few from5-,6-, 5,6-, 6,6-and 5,6,7-membered rings. Due to the growing use of combinatorial chemistry in various applications, use of polymer-supported methodologies have increased. The oxidation potentials as well as the hydroxyl radical scavenging activities for some pyrazol-3-ones have been detected and compared with edavarone's. The Schiff base 4-[(4-hydroxy-3-hydroxymethylbenzylidene) amino]-1,5-dimethyl-2-phenyl-1,2 dihydropyrazol-3-one retards the corrosion of steel. The chapter concludes that certain azopyrazol-3-ones may prove useful as labels for chromatographic analysis of carbohydrates.

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