An efficient copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling of 1-chloroisoquinolines in the formation of 1-alkynyl-3-substituted isoquinolines-Science-Chemical Encyclopedia-lookchem

An efficient copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling of 1-Chloroisoquinoline (cas 19493-44-8)s in the formation of 1-alkynyl-3-substituted isoquinolines
Add time:08/21/2019 Source:sciencedirect.com

An efficient, copper-free Sonogashira coupling reaction of 1-chloroisoquinolines and terminal alkynes, catalyzed by Pd(OAc)2/Ruphos, in the presence of Et3N and tetrahydrofuran leads to the formation of 1-alkynyl-3-substituted isoquinolines in good yields.

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