Add time:08/28/2019 Source:sciencedirect.com
The dispersion of stratum corneum (SC) into intact cells has been studied in aqueous mixed micelle solutions containing α-Terpineol (α-T) solubilized in solutions of N,N-Dimethyldodecylamine (cas 112-18-5) oxide (C12,DMAO). The dispersion was found to be most effective when α-T is solubilized in the saturated state, and the sizes of the mixed micelles become larger with increasing concentrations of solubilized α-Terpineol (α-T) at pH 8.4.This dispersion effect was expected to be caused by the stronger solubilizing power of molecular complexes formed among C12DMAO and α-T in binary mixed solutions. These intermolecular interactions in mixed micelles were confirmed using 1H nuclear magnetic resonance (1H-NMR). The proposed mechanisms for the removal of intercellular lipids such as ceramides, cholesterol and their derivatives, which play an important role as adhesives among the corneocytes and for dispersing SC into intact cells, were confirmed by data obtained from the 1H-NMR and light scattering measurements.
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