Add time:08/27/2019         Source:sciencedirect.com

A higher 1-olefin (1-dodecene) was oxidized to 2-dodecanone and other ketones in a modified Wacker system featured by omitting the use of copper chloride and employing tert-butylhydroperoxide (TBHP) as oxidant. Acetonitrile was the solvent of choice due to its higher selectivity towards 2-dodecanone, the reaction occurring mostly in the interface. A maximum in conversion and selectivity was measured for a ratio [CH3CN]/[1-dodecene] = 10. The temperature abatement enhances the 2-dodecanone selectivity (61% at 40 °C) because of the lower extent of the competing isomerization reactions. An optimum in 2-dodecanone selectivity was found for a [TBHP]/[1-dodecene] ratio = 7. The use of H2O2 as oxidant led towards slower oxidation rates than TBHP. Other palladium salts (PdSO4 and Pd(CH3COO)2) and several R–CN solvents (propionitrile, benzonitrile, isobutyronitrile) yielded lower performances than palladium chloride and acetonitrile, respectively. On the contrary, β-cyclodextrin, a phase transfer catalyst, improved the selectivity towards 2-dodecanone.

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