Add time:08/27/2019         Source:sciencedirect.com

The level of LACTATE (cas 113-21-3) and hypoxia inducible factor (HIF) in cells has effect on tumor growth and drug resistance. The glycolysis of tumors could be inhibited by reducing the expression of lactate dehydrogenase A (LDHA) or the mutual conversion of lactic acid and pyruvic acid. To develop a bifunctional nanoparticle as both the cleaner of lactate and attenuator of glycolysis, a NIR (near infrared) responsive nanoparticle ([email protected]) was synthesized and characterized. The [email protected] catalyzed the oxidation of lactate to pyruvate under NIR irradiation. In vitro assay results demonstrate that [email protected] can decrease the activity of LDHA and attenuate the conversion of lactate to pyruvate. Moreover, [email protected] can inhibit the expression of HIF-1 and decrease the ATP level in HepG-1 cells. Our work demonstrates that [email protected] can be a NIR enhanced glycolytic inhibitor for cancer interventional treatment.

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