Add time:07/13/2019         Source:sciencedirect.com

The present work reveals the synthesis and antiproliferative effect of a series of 2, 3 disubstituted 4-thiazolidinone analogues on human leukemic cells. The chemical structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Compound methyl 3-methoxy-4-(4-oxo-3-(5-(piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl)benzoate (5) displayed potent activity (IC50 9.71, 15.24 and 19.29 μM) against Nalm6, K562, Jurkat cells. Cell cycle analysis and mitochondrial membrane potential further confirmed that compound 5 is cytotoxic and able to induce cell death.

We also recommend Trading Suppliers and Manufacturers of 3-METHYL-1-(5-NITROPYRIDIN-2-YL)PIPERAZINE (cas 773879-30-4). Pls Click Website Link as below: cas 773879-30-4 suppliers