Add time:08/21/2019         Source:sciencedirect.com

The absorption and fluorescence spectra of dothiepin and doxepin have been recorded in solvents of different polarities and β-cyclodextrin (β-CD). The inclusion complex of both drugs with β-CD is investigated by UV–visible, fluorimetry, DFT, FT-IR and scanning electron microscopy (SEM). In all solvents, the absorption and emission maxima of dothiepin are red shifted than doxepin. β-CD studies reveal that both drugs form a mixture inclusion complex with β-CD. The structured longer wavelength emission in β-CD aqueous solution suggests that viscosity plays major role in the β-CD. This study also confirms van der Waals forces and hydrophobic interactions are the driving forces for the inclusion complexes.

► We investigate the spectral characteristics of dothiepin and doxepin drugs. ► In all solvents dothiepin maximum is red shifted than doxepin. ► The inclusion complexes were analyzed by UV–Visible and fluorometric methods. ► We calculated the stoichiometry and binding constant of the inclusion complex. ► The dothiepin and doxepin drugs form 1:3 inclusion complexes with β-cyclodextrin.

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