Add time:08/25/2019         Source:sciencedirect.com

High pressure liquid chromatography coupled to photodiode array detector and capillary gas chromatography coupled to mass spectrometry were employed to quantify DOTHIEPIN (cas 113-53-1) in biological fluids, tissues and hair in a death attributed to oral dothiepin (ProthiadenR) ingestion. The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concentration of 1.89 ng/mg hair. Results are discussed in the light of the existing literature.

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