Add time:08/22/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses Penicillin G, Potassium. Penicillin G was first crystallized at Squibb by MacPhillamy, Wintersteiner and Alicino, where the existence of sulfur in the molecule was first noted by Alicino due to its characteristic odor. The structure of benzylpenicillin was established by Dorothy Hodgkin and Barbara Lois in May 1945, using three-dimensional x-ray crystallography. Thus, it was shown that penicillin contained a previously unknown ring system. Penicillin G Potassium is the United States adopted name. Potassium benzylpenicillin is a white, free flowing crystalline powder with a faint pungent odor characteristic of penicillins. The compound itself should not be mixed with acids, alcohol, bases, ephredrine, glycerol, iodine and iodides, naphthalene oils, oxidizing agents, resorcinol, salts of heavy metals, vitamin B, and zinc oxide. The significant adverse reaction to benzylpenicillin is the induction of an allergic reaction as severe as anaphylactic shock leading to death.

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