Lewis acid mediated intramolecular C–O bond formation of alkanol-epoxide leading to substituted morpholine and 1,4-oxazepane derivatives: total synthesis of (±)–Viloxazine-Science-Chemical Encyclopedia-lookchem

Lewis acid mediated intramolecular C–O bond formation of alkanol-epoxide leading to substituted morpholine and 1,4-oxazepane derivatives: total synthesis of (±)–Viloxazine
Add time:08/24/2019 Source:sciencedirect.com

Substituted morpholines have been efficiently synthesised in good yields from nitrogen tethered alkanol-epoxide mediated by boron trifluoride etherate. The methodology has been used for the total synthesis of (±)-viloxazine.

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