Stereoselective synthesis of 3′-fluoro- and 3′-azido-4′-methyl-2′,3′-D-glycero-pentofuranoside-5-fluorouracils-Science-Chemical Encyclopedia-lookchem

Stereoselective synthesis of 3′-fluoro- and 3′-azido-4′-methyl-2′,3′-D-glycero-pentofuranoside-5-fluorouracils
Add time:08/23/2019 Source:sciencedirect.com

Total stereoselective synthesis of 2,3-dideoxy-3-fluoro- and 2,3-dideoxy-3-azido-d-glycero-pentose and their condensation with 5-fluorouracil is described. The key step in this synthesis is nucleophilic cleavage of a chiral epoxyalcohol, prepared from commercially available 2-methyl-2-butenal.

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