Add time:08/24/2019         Source:sciencedirect.com

Hedgehog signaling pathway inhibitors are emerging as new therapeutic intervention against cancer. A novel series of N-(2-pyrimidinylamino) benzamide derivatives as hedgehog signaling pathway inhibitors were designed and synthesized. Most compounds presented significant inhibitory effect on hedgehog signaling pathway, among which 21 compounds exhibited more potent than vismodegib. Furthermore, compound 6a showed moderate pharmacokinetic properties in vivo, representing a promising lead compound for further exploration.

We also recommend Trading Suppliers and Manufacturers of 2-(TRIFLUOROMETHOXY)BENZAMIDE (cas 127979-74-2). Pls Click Website Link as below: cas 127979-74-2 suppliers