Add time:08/25/2019         Source:sciencedirect.com

D-[35S(U)]mya-inositol 1,4,5-trisphosphorothioate ([35S]InsPS3), a synthetic, metabolically stable analogue of inositol 1,4,5-trisphosphate (InsP3) binds with high affinity (Ka 58.6±9.1 nM) to rat cerebellar revealing a high density of specific binding sites (Dmax 21.5±2.1 pmol/mg of protein). Comparison with [3H]InsP3 binding reveals a higher density of sites labelled by [35S]InsPS3 and complex competition curves for displacement of specific [35S]insPS3 by InsP3. The results suggests that [35S]InsPS3 labels two sites in rat cerebellar membranes with equal affinity: the InsP3 receptor and a site that displays low affinity for InsP3.

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