Add time:07/15/2019         Source:sciencedirect.com

Single dose oral treatments of KAMALA (cas 12624-07-6), the dried, powdered fruit of Mallotus philippinensis (250, 375, 500 and 750 mg kg−1 liveweight), were compared with a single dose of fenbendazole (Panacur®) (10 mg kg−1 liveweight, as recommended by the manufacturer) to determine the relative effectiveness of each against gastrointestinal nematodes with a direct life-cycle. Twenty-eight castrated male goats were made parasite free and then inoculated with mixed cultures of infective, direct life-cycle nematode larvae. The fecal eggs per gram (EPG) counts for the groups treated with 250 and 375 mg kg−1 of kamala did not significantly (P > 0.05) drop (pre-treatment means 2071 ± 1149 and 2245 ± 1130, respectively) over a 26 day period (day 26 means 3217 ± 1604 and 2942 ± 2076, respectively). The EPG counts for the groups treated with 500 and 750 mg kg−1of kamala did not significantly (P > 0.05) drop (pre-treatment means 534 ± 212 and 9440 ± 8693, respectively) overa 15day period (day 15 means 338 ± 158 and 2202 ± 1930, respectively). Fenbendazole affected a significant decrease (P < 0.001) in EPG counts from pre-treatment values (mean 1864 ± 1030) after a period of 5 days (mean 0.0 ± 0.0). Although interviews conducted in Quetta, Pakistan, indicate that there is a great dependency upon kamala as a general anthelminthic in the area, it is concluded that kamala is not effective in eliminating direct life-cycle gastrointestinal nematodes in goats. Therefore, kamala should not be used alone as a treatment for nematode infections of the gastrointestinal tract.

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