Add time:08/26/2019         Source:sciencedirect.com

Indoles constitute extensively explored heterocyclic ring systems with a wide range of applications in pathophysiological conditions such as cancer, microbial and viral infections, inflammation, depression, migraine, emesis, hypertension, and so on. Presence of an indole nucleus in amino acid tryptophan makes it prominent in phytoconstituents such as perfumes, neurotransmitters, auxins (plant hormones), indole alkaloids, and so on. The interesting molecular architecture of indoles makes them suitable candidates for drug development. This chapter provides an overview of the chemistry, biology, and toxicology of indoles, focusing on their application as multitarget directed drugs. This compiled information may serve as a benchmark for the alteration of existing ligands to design novel potent molecules with lesser side effects.

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