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  • Effects of 3β-(β,β-dimethylaminoethoxy)-steroids on sterol metabolism and development of Bombyx mori☆
  • Add time:08/23/2019         Source:sciencedirect.com

    Three 3β-(β,β-dimethylaminoethoxy)-substituted steroids, DAEA, DAEAM, and DAEC, have been found to be potent blockers of the enzyme system participating the conversion of β-sitosterol into cholesterol in the silkworm larvae. Thus, a preliminary site of inhibitory action of these steroids is the terminal step in this conversion—from desmosterol to cholesterol, and a secondary site of inhibitory action of DAEA and DAEAM is the initial step of this conversion—from β-sitosterol to its immediate metabolite. These inhibitors have been proved to prevent larval development and metamorphosis of the silkworm that has been appreciably counteracted by administration of the moulting hormone.

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