Diastereoselective synthesis of anti-3-hydroxy-2-trifluoromethyl carboxylic acids-Science-Chemical Encyclopedia-lookchem

Diastereoselective synthesis of anti-3-hydroxy-2-trifluoromethyl carboxylic acids
Add time:08/23/2019 Source:sciencedirect.com

Unlike the hydrocarbon analogs, this first report of enolboration–aldolization of 3,3,3-trifluoropropanoic acid provides essentially pure anti-diastereomers of α-trifluoromethyl-β-hydroxy carboxylic acids in 77–90% yields.

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