Add time:08/21/2019         Source:sciencedirect.com

Synthesis and structure–activity relationships (SAR) of RARα-selective agonists are discussed. 4-[5-(5,8-Dimethyl-2H-3-chromenyl)-1H-2-pyrrolyl]benzoic acid (12a), which possesses a flat structural moiety and an oxygen atom at the hydrophobic part, showed highly selective transactivation activity at the RARα receptor.

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