Add time:08/22/2019         Source:sciencedirect.com

The effects of the recently described human α-calcitonin gene-related peptide (CGRP), human β-CGRP and rat α-CGRP have been compared with those of the vasodilator sodium nitroprusside, on the rat and rabbit isolated heart. Hearts were perfused at constant flow and [Arg8]-vasopressin was used to increase coronary perfusion pressure. In the rat heart, the order of potency for evoking cumulative dose-dependent falls in perfusion pressure was human β-CGRP>rat α-CGRP>human α-CGRP>sodium nitroprusside. In the same preparations the three CGRPs (but not sodium nitroprusside) elicited cumulative dose-related increases in heart rate. In the rabbit heart the order of potency for vasodilatation was rat α-CGRP>human α-CGRP>sodium nitroprusside. In marked contrast to results from the rat, neither rat α-CGRP nor human α-CGRP altered heart rate in the rabbit isolated heart. These results show that human α- and β-CGRP and rat α-CGRP are vasodilators in the coronary vasculature, but that there is species variation as CGRP had a positive chronotropic effect in the rat heart but not in the rabbit heart.

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