Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A2A receptor antagonists-Science-Chemical Encyclopedia-lookchem

Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A2A receptor antagonists
Add time:08/26/2019 Source:sciencedirect.com

The discovery and synthesis of a series of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A2A receptor antagonists from a small-molecule combinatorial library using a high-throughput radioligand-binding assay is described. Antagonists were further characterized in the A2A binding assay and an A1 selectivity assay. Selected examples exhibited excellent affinity for A2A and good selectivity versus the A1 receptor.

We also recommend Trading Suppliers and Manufacturers of 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID (cas 108128-39-8). Pls Click Website Link as below: cas 108128-39-8 suppliers

Prev:Synthesis and in vitro leishmanicidal activity of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles
Next: Research paperSynthesis of (Z)-1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents)

Click to view details

Encyclopedia