Add time:08/22/2019         Source:sciencedirect.com

We report here the synthesis, characterization of seventeen (E)-2-methyl-3-ferrocenyl-N-acrylamides. The single crystal structures of the key intermediate b and two target compounds d5 and d6 were confirmed by X-ray crystallographic analysis. Antitumor activity of all compounds was tested in vitro. Compound d1 was the most significant one against B16F10 cell line, indicating that it could be a good candidate for further study. Furthermore, cancer cell apoptosis assay was performed and the result indicated that compound d1 effectively fueled B16F10 cells apoptosis in a dose-dependent manner.

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