Add time:08/25/2019         Source:sciencedirect.com

Secretin, a 27-amino-acid peptide hormone produced by intestinal S cells, is released into the duodenum primarily in response to pH changes following food ingestion. Its major target organs include the pancreas, stomach, and gallbladder. Secretin affects pancreatic bicarbonate secretion, gastric acid secretion, and motility and augmentation of bile flow. Secretin has been found to be altered in some clinical conditions and is currently used as a diagnostic tool for assessing pancreatic function in chronic pancreatitis, in identification of the main pancreatic duct, and in diagnosis of gastrinoma (Zollinger–Ellison syndrome).

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