Add time:07/14/2019         Source:sciencedirect.com

As an important member of anti-apoptotic Bcl-2 protein, myeloid cell leukemia sequence 1 (Mcl-1) protein is an attractive target for cancer therapy. In this study, a new series of pyrrolidine derivatives as Mcl-1 inhibitors were developed by mainly modifying the amino acid side chain of compound 1. Among them, compound 18 (Ki = 0.077 μM) exhibited better potent inhibitory activities towards Mcl-1 protein compared to positive control Gossypol (Ki = 0.18 μM). In addition, compound 40 possessed good antiproliferative activities against PC-3 cells (Ki = 8.45 μM), which was the same as positive control Gossypol (Ki = 7.54 μM).

We also recommend Trading Suppliers and Manufacturers of Pyrrolidine, 1-[(4-bromophenyl)methyl]- (cas 4897-55-6). Pls Click Website Link as below: cas 4897-55-6 suppliers