Add time:08/26/2019         Source:sciencedirect.com

A standardized procedure for the routine measurement of hepatic mixed function oxidases including aminopyrine N-demethylase, p-nitroanisole O-demethylase, aniline hydroxylase, and azoreductase was used to examine enzyme alteration due to chronic drug administration. Oral treatment of monkeys or rats with either racemic MEPHOBARBITAL (cas 115-38-8) or d-mephobarbital significantly increased liver weights and hepatic microsomal enzyme activities. Racemic mephobarbital-treated rats demonstrated higher hepatic enzyme activities compared to d-mephobarbital-treated rats. No differences were noted in the degree of induction of enzyme activities due to either isomer in the monkey.

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