Add time:07/15/2019         Source:sciencedirect.com

The intraperitoneal administration of acetoxycycloheximide to rats in vivo stimulates the incorporation of l-(14C)-phenylalanine into protein in a liver microsomal system in vitro after 24 hours. The increased incorporation of the system is associated predominantly with the microsomal fraction and to a minor extent with factors that may be present in the cell sap. Two microsomal effects can be differentiated. The first of these, dependent on endogenous messenger RNA, is more pronounced and prolonged, but is inhibited in the 6-hour period after the administration of the drug. The second, involving microsomal sensitivity to exogenous messenger RNA, is not initially inhibited.We find that female animals are more susceptible to acetoxycyoloheximide and more sensitive to the lethal action of the drug than the males.Both in vitro stimulation and in vivo inhibition of amino acid incorporation into protein are almost completely eliminated in hypophysectomized rats, although these responses to the drug are characteristic of intact animals. It would therefore appear that the mechanism of the action of acetoxycycloheximide depends on the integrity of the pituitary gland.In experiments with adrenalectomized rats we were able to demonstrate that they reacted to acetoxycycloheximide in a similar manner to intact animals.

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