Add time:08/25/2019         Source:sciencedirect.com

The role of NF-κB in the Ewing’s sarcoma family of tumours (ESFT) and their response to fenretinide has been investigated. Basal levels of phosphorylated NF-κB were low in all ESFT cells. BAY 11-7082 (cas 19542-67-7) decreased cell viability, which was accompanied by caspase-3 cleavage. This was independent of the increase in reactive oxygen species, p38MAPK phosphorylation and expression of NF-κB target proteins. NF-κB knockdown did not induce death under normal growth conditions, but did reduce TNFα-dependent cell survival. Fenretinide-induced apoptosis was independent of NF-κB. BAY 11-7082-induced cell death through an NF-κB-independent mechanism and enhanced cell death when combined with fenretinide.

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