Add time:08/22/2019         Source:sciencedirect.com

A series of analogs of 1,25-dihydroxyergocalciferol (1–4) was synthesized and screened for their antiproliferative activity in vitro. The structure of new analogs was designed based on biological activity of the previously obtained side-chain modified analogs of vitamin D2 and D3. The analogs were obtained by the Julia olefination of C22-vitamin D sulfone 11 with side-chain aldehyde 15. The analogs were tested for their antiproliferative activity against the cells of human breast cancer lines T47D and MCF7 as well as human and mouse leukemia lines, HL-60 and WEHI-3, respectively. Analog 2 (PRI-1907) showed the strongest antiproliferative activity out of the present series of analogs of 1,25-dihydroxyvitamin D2 with the mono homologated and double unsaturated side chain. The activity of 2 was 3–150 times stronger, depending on the cell line, than that of 1,25-dihydroxycholecalciferol (calcitriol), used as standard.

We also recommend Trading Suppliers and Manufacturers of (24E)-3-Oxo-5α-lanosta-7,9(11),24-triene-26-al (cas 104700-98-3). Pls Click Website Link as below: cas 104700-98-3 suppliers